New publication from the Systems Immunology Lab of NII in the EMBO Journal!
Using single-cell and bulk transcriptomics analyses, deep immunophenotyping studies and cell-type specific knockout mouse strains, the research group articulates how micronutrient and immune signalling pathways crosstalk in regulating intestinal homeostasis and inflammation.
The non-canonical NF-kappaB pathway, otherwise known for its role in immune-organ development, is activated in intestinal dendritic cells from inflammatory bowel disease (IBD) patients and colitogenic mice. This non-canonical NF-kB signalling subverts the gut-protective vitamin A-retinoic acid axis, fueling dysbiosis and aberrant intestinal inflammation. On the other hand, DC-specific disruption of this pathway protected mice from experimental colitis. Overall, this investigation promises to expand the therapeutic opportunities for inflammatory intestinal pathologies.
Read the full paper here: https://bit.ly/3LFK435
Alvina Deka, #NaveenKumar, Soumen Basak, Amit Awasthi, Debarka Sengupta, Bhabatosh Das, Translational Health Science and Technology Institute (THSTI), Indraprastha Institute of Information Technology, Delhi, Department of Biotechnology)