John Stamos to Guest Star on UnPrisoned Alongside Kerry Washington and Delroy Lindo (Exclusive)

John Stamos won’t mince words when he appears in the second season of UnPrisoned.

The actor, 60, will guest star on the Hulu comedy as Murphy, a bestselling author, reality star and self-proclaimed “family radical healing coach,” PEOPLE has learned. The “cut-to-the-chase” type therapist prides himself in being very direct with patients about “what’s wrong with them.”

Stamos is one of several actors joining the upcoming season, premiering July 17, with other guest stars including Jamie Chung, Brandee Evans and Oliver Hudson. Brenda Strong, who appeared in the first season as Delroy Lindo’s onscreen love interest Nadine, will also return as a guest star.

Season 2 of UnPrisoned picks up where the season 1 finale left off, with Edwin (Lindo) deciding to move out of Paige's (Kerry Washington) home.  According to the synopsis, this season will see Edwin work on figuring out his life after getting out of prison during the season 1 pilot. Paige’s therapy practice, meanwhile, is in jeopardy and Finn (Faly Rakotohavana) must navigate his anxiety. The Alexander family turn to Murphy, who tosses out all the conventional rules of therapy to “free them of their issues, old wounds and family secrets holding them back.”

Stamos is no stranger to playing a therapist, portraying the pot-smoking Dr. Nicky Reynolds in You’s first and second seasons, who is wrongfully imprisoned for the murder of Guinevere Beck (Elizabeth Lail). Despite being innocent of Guinevere’s murder, the existential feeling Dr. Reynolds, contends in the season 2 episode entitled “Love, Actually” that he's “guilty” of other things, including destroying his marriage, his wife and his kids and of "using" Guinevere.

“I’m guilty of using her [Guinevere] — and she’s not the first. … She’s just the first to end up dead,” Dr. Reynolds says in the episode.

Stamos rose to fame playing Blackie Parrish on General Hospital from 1982 to 1984, for which he earned a Daytime Emmy nomination. He landed on another hit show, Full House, portraying Jesse Katsopolis, from 1987 to 1995 — a role he would later reprise for the Netflix sequel series Fuller House, which ran for five seasons, from 2016 to 2020.

"It's [Full House] a story critics can get contemptuous about but also one that moms and dads can enjoy with their kids," Stamos wrote in his 2023 memoir If You Would Have Told Me, adding the show "was sentimental in a way that feels brave" and displayed "a vulnerability that is almost retro."

During his decades-long career, the actor has also starred in TV projects including the Disney+ sports dramedy Big Shot and the Fox comedy Grandfathered, for which he won a People’s Choice Award in 2016 for favorite actor in a new TV series. He has also starred onstage in productions of How To Succeed in Business Without Really Trying, Cabaret, Bye Bye Birdie and Nine.

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Season 2 of UnPrisoned premieres July 17 on Hulu.