Lycopene and cardiovascular disease
- PMID: 10837319
- DOI: 10.1093/ajcn/71.6.1691S
Lycopene and cardiovascular disease
Abstract
Considerable evidence suggests that lycopene, a carotenoid without provitamin A activity found in high concentrations in a small set of plant foods, has significant antioxidant potential in vitro and may play a role in preventing prostate cancer and cardiovascular disease in humans. Tomato products, including ketchup, tomato juice, and pizza sauce, are the richest sources of lycopene in the US diet, accounting for >80% of the total lycopene intake of Americans. Unlike other carotenoids, lycopene is not consistently lower among smokers than among nonsmokers, suggesting that any possible preventive activity is not as an antioxidant. Instead, lycopene may have a cholesterol synthesis-inhibiting effect and may enhance LDL degradation. Available evidence suggests that intimal wall thickness and risk of myocardial infarction are reduced in persons with higher adipose tissue concentrations of lycopene. The question of whether lycopene helps to prevent cardiovascular disease can only be answered by a trial specifically evaluating its effectiveness in this area.
Similar articles
-
Tomato lycopene and its role in human health and chronic diseases.CMAJ. 2000 Sep 19;163(6):739-44. CMAJ. 2000. PMID: 11022591 Free PMC article. Review.
-
Dietary lycopene, tomato-based food products and cardiovascular disease in women.J Nutr. 2003 Jul;133(7):2336-41. doi: 10.1093/jn/133.7.2336. J Nutr. 2003. PMID: 12840203
-
Role of antioxidant lycopene in cancer and heart disease.J Am Coll Nutr. 2000 Oct;19(5):563-9. doi: 10.1080/07315724.2000.10718953. J Am Coll Nutr. 2000. PMID: 11022869 Review.
-
Antioxidant capacity of lycopene-containing foods.Int J Food Sci Nutr. 2001 Mar;52(2):143-9. doi: 10.1080/713671775. Int J Food Sci Nutr. 2001. PMID: 11303462
-
Comparative multiple dose plasma kinetics of lycopene administered in tomato juice, tomato soup or lycopene tablets.Eur J Nutr. 2004 Oct;43(5):304-12. doi: 10.1007/s00394-004-0476-0. Epub 2004 Jan 26. Eur J Nutr. 2004. PMID: 15309451 Clinical Trial.
Cited by
-
Changes in Intake and Major Food Sources of Carotenoids among U.S. Adults between 2009-2018.Metabolites. 2023 Dec 24;14(1):13. doi: 10.3390/metabo14010013. Metabolites. 2023. PMID: 38248816 Free PMC article.
-
Effects of tomato ketchup and tomato paste extract on hepatic lipid accumulation and adipogenesis.Food Sci Biotechnol. 2023 Feb 6;32(8):1111-1122. doi: 10.1007/s10068-023-01244-x. eCollection 2023 Jul. Food Sci Biotechnol. 2023. PMID: 37215254 Free PMC article.
-
A Tomato EMS-Mutagenized Population Provides New Valuable Resources for Gene Discovery and Breeding of Developmental Traits.Plants (Basel). 2022 Sep 20;11(19):2453. doi: 10.3390/plants11192453. Plants (Basel). 2022. PMID: 36235319 Free PMC article.
-
Process Development for the Instant Quantification of Lycopene from Agricultural Produces Using Supercritical Fluid Chromatography-Diode Array Detector (SFC-DAD).Foods. 2022 Feb 11;11(4):522. doi: 10.3390/foods11040522. Foods. 2022. PMID: 35205996 Free PMC article.
-
Italian Tomato Cultivars under Drought Stress Show Different Content of Bioactives in Pulp and Peel of Fruits.Foods. 2022 Jan 20;11(3):270. doi: 10.3390/foods11030270. Foods. 2022. PMID: 35159422 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical