A look at epidermal barrier function in atopic dermatitis: physiologic lipid replacement and the role of ceramides
- PMID: 22825649
A look at epidermal barrier function in atopic dermatitis: physiologic lipid replacement and the role of ceramides
Erratum in
- Skin Therapy Lett. 2013 Sep-Oct;18(6):7
Abstract
This review summarizes and discusses the role and efficacy of moisturizers, particularly the more recently introduced ceramide-based formulations, in the skin care regimen of patients with both active and quiescent atopic dermatitis (AD). It is now well established that a complex interplay of environmental and genetic factors are responsible for disease onset and chronicity. Indeed, several novel genetic mechanisms have been recently discovered to be associated with AD pathogenesis. Moreover, it is increasingly recognized that the epidermal barrier plays a critical role in the initiation, perpetuation, and exacerbation of AD. The skin of patients with AD harbors several defects in epidermal barrier function, including filaggrin and ceramides. An improved understanding of these etiopathogenic factors has led to the development of topical ceramide-dominant moisturizers to replace the deficient molecules and re-establish the integrity of barrier defenses. Some of these products have demonstrated efficacy in the treatment of adult and childhood AD that are similar to mid-potency topical steroids. More importantly, they have been shown to be safe with very few associated side-effects. We recommend the addition of such new agents as both the first step of treatment and in the maintenance of clinically quiescent skin of patients with AD.
Similar articles
-
Are the new moisturizers more effective?Curr Opin Pediatr. 2009 Aug;21(4):486-90. doi: 10.1097/MOP.0b013e32832cfd3b. Curr Opin Pediatr. 2009. PMID: 19543089 Review.
-
Moisturizers versus Current and Next-Generation Barrier Repair Therapy for the Management of Atopic Dermatitis.Skin Pharmacol Physiol. 2019;32(1):1-7. doi: 10.1159/000493641. Epub 2018 Oct 18. Skin Pharmacol Physiol. 2019. PMID: 30336483 Review.
-
A study to assess the occlusivity and moisturization potential of three topical corticosteroid products using the skin trauma after razor shaving (STARS) bioassay.J Drugs Dermatol. 2014 May;13(5):582-5. J Drugs Dermatol. 2014. PMID: 24809882 Clinical Trial.
-
ARTICLE: Evolution of Skin Barrier Science for Healthy and Compromised Skin.J Drugs Dermatol. 2021 Apr 1;20(4):s3-s9. doi: 10.36849/JDD.2021.589a. J Drugs Dermatol. 2021. PMID: 33852254 Review.
-
Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity.J Am Acad Dermatol. 2002 Aug;47(2):198-208. doi: 10.1067/mjd.2002.124617. J Am Acad Dermatol. 2002. PMID: 12140465
Cited by
-
Efficacy of Heparinoid Cream Containing Pseudo-Ceramide for Remission of Atopic Dermatitis.Clin Cosmet Investig Dermatol. 2021 Dec 8;14:1839-1847. doi: 10.2147/CCID.S337930. eCollection 2021. Clin Cosmet Investig Dermatol. 2021. PMID: 34949930 Free PMC article.
-
Diet and Skin Barrier: The Role of Dietary Interventions on Skin Barrier Function.Dermatol Pract Concept. 2021 Jan 29;11(1):e2021132. doi: 10.5826/dpc.1101a132. eCollection 2021 Jan. Dermatol Pract Concept. 2021. PMID: 33614213 Free PMC article. Review.
-
The Role of MicroRNAs in Epidermal Barrier.Int J Mol Sci. 2020 Aug 12;21(16):5781. doi: 10.3390/ijms21165781. Int J Mol Sci. 2020. PMID: 32806619 Free PMC article. Review.
-
Skin Barriers in Dermal Drug Delivery: Which Barriers Have to Be Overcome and How Can We Measure Them?Pharmaceutics. 2020 Jul 20;12(7):684. doi: 10.3390/pharmaceutics12070684. Pharmaceutics. 2020. PMID: 32698388 Free PMC article. Review.
-
Molecular Mechanism of Epidermal Barrier Dysfunction as Primary Abnormalities.Int J Mol Sci. 2020 Feb 11;21(4):1194. doi: 10.3390/ijms21041194. Int J Mol Sci. 2020. PMID: 32054030 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical