The regulatory role and clinical application prospects of circRNA in the occurrence and development of CNS tumors
- PMID: 37953502
- PMCID: PMC11017455
- DOI: 10.1111/cns.14500
The regulatory role and clinical application prospects of circRNA in the occurrence and development of CNS tumors
Abstract
Background: Central nervous system (CNS) tumors originate from the spinal cord or brain. The study showed that even with aggressive treatment, malignant CNS tumors have high mortality rates. However, CNS tumor risk factors and molecular mechanisms have not been verified. Due to the reasons mentioned above, diagnosis and treatment of CNS tumors in clinical practice are currently fraught with difficulties. Circular RNAs (circRNAs), single-stranded ncRNAs with covalently closed continuous structures, are essential to CNS tumor development. Growing evidence has proved the numeral critical biological functions of circRNAs for disease progression: sponging to miRNAs, regulating gene transcription and splicing, interacting with proteins, encoding proteins/peptides, and expressing in exosomes.
Aims: This review aims to summarize current progress regarding the molecular mechanism of circRNA in CNS tumors and to explore the possibilities of clinical application based on circRNA in CNS tumors.
Methods: We have summarized studies of circRNA in CNS tumors in Pubmed.
Results: This review summarized their connection with CNS tumors and their functions, biogenesis, and biological properties. Furthermore, we introduced current advances in clinical RNA-related technologies. Then we discussed the diagnostic and therapeutic potential (especially for immunotherapy, chemotherapy, and radiotherapy) of circRNA in CNS tumors in the context of the recent advanced research and application of RNA in clinics.
Conclusions: CircRNA are increasingly proven to participate in decveloping CNS tumors. An in-depth study of the causal mechanisms of circRNAs in CNS tomor progression will ultimately advance their implementation in the clinic and developing new strategies for preventing and treating CNS tumors.
Keywords: CNS tumors; chemotherapy; circRNA; immunotherapy; radiotherapy.
© 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.
Conflict of interest statement
There are no competing interests.
Figures
![FIGURE 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/11017455/bin/CNS-30-e14500-g004.gif)
![FIGURE 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/11017455/bin/CNS-30-e14500-g001.gif)
![FIGURE 3](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/11017455/bin/CNS-30-e14500-g002.gif)
Similar articles
-
CircRNA: a rising star in plant biology.J Genet Genomics. 2022 Dec;49(12):1081-1092. doi: 10.1016/j.jgg.2022.05.004. Epub 2022 May 27. J Genet Genomics. 2022. PMID: 35644325 Review.
-
Circular RNAs: Emerging roles and new insights in human cancers.Biomed Pharmacother. 2023 Sep;165:115217. doi: 10.1016/j.biopha.2023.115217. Epub 2023 Jul 26. Biomed Pharmacother. 2023. PMID: 37506578 Review.
-
Advances in Circular RNA and Its Applications.Int J Med Sci. 2022 May 27;19(6):975-985. doi: 10.7150/ijms.71840. eCollection 2022. Int J Med Sci. 2022. PMID: 35813288 Free PMC article. Review.
-
Biological role and regulation of circular RNA as an emerging biomarker and potential therapeutic target for cancer.Mol Biol Rep. 2024 Feb 10;51(1):296. doi: 10.1007/s11033-024-09211-3. Mol Biol Rep. 2024. PMID: 38340202 Review.
-
Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression.J Exp Clin Cancer Res. 2023 Apr 15;42(1):86. doi: 10.1186/s13046-023-02657-6. J Exp Clin Cancer Res. 2023. PMID: 37060016 Free PMC article. Review.
References
-
- Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209‐249. - PubMed
-
- Quader S, Kataoka K, Cabral H. Nanomedicine for brain cancer. Adv Drug Deliv Rev. 2022;118:114115. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources