Assessment of the photoprotective potential and structural characterization of secondary metabolites of Antarctic fungus Arthrinium sp
- PMID: 38141073
- DOI: 10.1007/s00203-023-03756-w
Assessment of the photoprotective potential and structural characterization of secondary metabolites of Antarctic fungus Arthrinium sp
Abstract
Interest in Antarctic fungi has grown due to their resilience in harsh environments, suggesting the presence of valuable compounds from its organisms, such as those presenting photoprotective potential, since this environment suffers the most dangerous UV exposure in the world. Therefore, this research aimed to assess the photoprotective potential of compounds from sustainable marine sources, specifically seaweed-derived fungi from Antarctic continent. These studies led to discovery of photoprotective and antioxidant properties of metabolites from Arthrinium sp., an endophytic fungus from Antarctic brown algae Phaeurus antarcticus. From crude extract, fractions A-I were obtained and compounds 1-6 isolated from E and F fractions, namely 3-Hydroxybenzyl alcohol (1), (-)-orthosporin (2), norlichexanthone (3), anomalin B (4), anomalin A (5), and agonodepside B (6). Compounds 1, 2, and 6 were not previously reported in Arthrinium. Fraction F demonstrated excellent absorbance in both UVA and UVB regions, while compound 6 exhibited lower UVB absorbance, possibly due to synergistic effects. Fraction F and compound 6 displayed photostability and were non-phototoxic to HaCaT cells. They also exhibited antioxidant activity by reducing intracellular ROS production induced by UVA in keratinocyte monolayers and reconstructed human skin models (resulting in 34.6% and 30.2% fluorescence reduction) and did not show irritation potential in HET-CAM assay. Thus, both are promising candidates for use in sunscreens. It is noted that Fraction F does not require further purification, making it advantageous, although clinical studies are necessary to confirm its potential applicability for sunscreen formulations.
Keywords: Antioxidant; Arthrinium; Marine Antarctic natural products; Photoprotection; Reconstructed human skin.
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Similar articles
-
In Vitro Evaluation of the Photoprotective Potential of Quinolinic Alkaloids Isolated from the Antarctic Marine Fungus Penicillium echinulatum for Topical Use.Mar Biotechnol (NY). 2021 Jun;23(3):357-372. doi: 10.1007/s10126-021-10030-x. Epub 2021 Apr 2. Mar Biotechnol (NY). 2021. PMID: 33811268
-
Propolis as potential cosmeceutical sunscreen agent for its combined photoprotective and antioxidant properties.Int J Pharm. 2011 Feb 28;405(1-2):97-101. doi: 10.1016/j.ijpharm.2010.11.052. Epub 2010 Dec 4. Int J Pharm. 2011. PMID: 21134430
-
Photoprotective potential of metabolites isolated from algae-associated fungi Annulohypoxylon stygium.J Photochem Photobiol B. 2018 Jan;178:316-322. doi: 10.1016/j.jphotobiol.2017.11.018. Epub 2017 Nov 21. J Photochem Photobiol B. 2018. PMID: 29175758
-
Current developments in the nanomediated delivery of photoprotective phytochemicals.Environ Sci Pollut Res Int. 2020 Nov;27(31):38446-38471. doi: 10.1007/s11356-020-10100-y. Epub 2020 Aug 6. Environ Sci Pollut Res Int. 2020. PMID: 32761528 Review.
-
Exploring Mycosporine-like Amino Acid UV-Absorbing Natural Products for a New Generation of Environmentally Friendly Sunscreens.Mar Drugs. 2023 Apr 19;21(4):253. doi: 10.3390/md21040253. Mar Drugs. 2023. PMID: 37103392 Free PMC article. Review.
Cited by
-
Evaluation of the photoprotective and antioxidant potential of an avobenzone derivative.Front Physiol. 2024 Feb 29;15:1347414. doi: 10.3389/fphys.2024.1347414. eCollection 2024. Front Physiol. 2024. PMID: 38487263 Free PMC article.
References
-
- Abdel-Lateff A, Klemke C, König GM, Wright AD (2003) Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus. J Nat Prod 66:706–708. https://doi.org/10.1021/np020518b - DOI - PubMed
-
- Afaq F, Zaid MA, Khan N, Dreher M, Mukhtar H (2009) Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin. Exp Dermatol 18:553–561. https://doi.org/10.1111/j.1600-0625.2008.00829.x - DOI - PubMed - PMC
-
- Afonso S, Horita K, Sousa e Silva JP, Almeida IF, Amaral MH, Lobão PA, Costa PC, Miranda MS, Esteves da Silva JC, Sousa Lobo JM (2014) Photodegradation of avobenzone: stabilization effect of antioxidants. J Photochem Photobiol B 140:36–40. https://doi.org/10.1016/j.jphotobiol.2014.07.004 - DOI - PubMed
-
- Alfaro C, Urios A, González MC, Moya P, Blanco M (2003) Screening for metabolites from Penicillium novae-zeelandiae displaying radical-scavenging activity and oxidative mutagenicity: isolation of gentisyl alcohol. Mutat Res 539:187–194. https://doi.org/10.1016/s1383-5718(03)00166-9 - DOI - PubMed
-
- Badiali C, Petruccelli V, Brasili E, Pasqua G (2023) Xanthones: biosynthesis and trafficking in plants. Fungi Lichens Plants 12(4):694. https://doi.org/10.3390/plants12040694 - DOI - PubMed
MeSH terms
Substances
Grants and funding
- N°64/2013/PROANTAR/MCTI/CNPq
- N°64/2013/PROANTAR/MCTI/CNPq
- N°64/2013/PROANTAR/MCTI/CNPq
- N°64/2013/PROANTAR/MCTI/CNPq
- N°64/2013/PROANTAR/MCTI/CNPq
- N°64/2013/PROANTAR/MCTI/CNPq
- #465637/2014-0/National Institute of Science and Technology (INCT:BioNat)
- #465637/2014-0/National Institute of Science and Technology (INCT:BioNat)
- #465637/2014-0/National Institute of Science and Technology (INCT:BioNat)
- #465637/2014-0/National Institute of Science and Technology (INCT:BioNat)
- #2014/50926-0 and 2017/03552-5/State of São Paulo Research Foundation (FAPESP)
- #2014/50926-0 and 2017/03552-5/State of São Paulo Research Foundation (FAPESP)
- #2014/50926-0 and 2017/03552-5/State of São Paulo Research Foundation (FAPESP)
- #2014/50926-0 and 2017/03552-5/State of São Paulo Research Foundation (FAPESP)
- #2014/50926-0 and 2017/03552-5/State of São Paulo Research Foundation (FAPESP)
- #2014/50926-0 and 2017/03552-5/State of São Paulo Research Foundation (FAPESP)
- #2014/50926-0 and 2017/03552-5/State of São Paulo Research Foundation (FAPESP)
- #2014/50926-0 and 2017/03552-5/State of São Paulo Research Foundation (FAPESP)
- #2014/50926-0 and 2017/03552-5/State of São Paulo Research Foundation (FAPESP)
- #2014/50926-0 and 2017/03552-5/State of São Paulo Research Foundation (FAPESP)
- #2014/50926-0 and 2017/03552-5/State of São Paulo Research Foundation (FAPESP)
LinkOut - more resources
Full Text Sources