- Owen Wilson
- Reggie
- Woody Harrelson
- Jake
- Amy Poehler
- Jenny
- George Takei
- S.T.E.V.E.
- Colm Meaney
- Myles Standish
- Keith David
- Chief Broadbeak
- Dan Fogler
- Governor Bradford
- Jimmy Hayward
- Ranger/President, Director, Screenwriter
- Kaitlyn Maher
- President's Daughter
- Carlos Alazraqui
- Amos
- Carlos Ponce
- Narrator/Alejandro
- Danny Carey
- Danny
- Jeff Biancalana
- General Sagan
- Robert Beltran
- Chief Massasoit
- Jimmy Hayward
- Ranger/President, Director, Screenwriter
- Scott Mosier
- Producer, Screenwriter
- Aron Warner
- Executive Producer
- John J. Strauss
- Executive Producer
- David I. Stern
- Executive Producer
- Dominic Lewis
- Original Music
- Chris Cartagena
- Film Editing
- Kevin R. Adams
- Art Director
- Kerry Rock
- Casting
