- Logan Lerman
- Percy Jackson
- Brandon T. Jackson
- Grover
- Alexandra Daddario
- Annabeth Chase
- Jake Abel
- Luke Castellan
- Douglas Smith
- Tyson
- Leven Rambin
- Clarisse
- Nathan Fillion
- Hermes
- Anthony Head
- Chiron
- Stanley Tucci
- Mr. D
- Mary Birdsong
- Gray Sister 1
- Yvette Nicole Brown
- Gray Sister 2
- Missi Pyle
- Gray Sister 3
- Connor Dunn
- Tereus
- Paloma Kwiatkowski
- Thalia
- Christopher Redman
- Reardon
- Robert Knepper
- Kronos
- Richard Yearwood
- Ganymede
- Ron Perlman
- Polyphemus
- Shohreh Aghdashloo
- Oracle
- Octavia Spencer
- Martha
- Craig Robinson
- George
- Thor Freudenthal
- Director
- Marc Guggenheim
- Screenwriter
- Karen Rosenfelt
- Producer
- Michael Barnathan
- Producer
- Chris Columbus
- Executive Producer
- Mark Radcliffe
- Executive Producer
- Mark Morgan
- Executive Producer
- Guy Oseary
- Executive Producer
- Greg Mooradian
- Executive Producer
- Shelly Johnson
- Cinematographer
- Mark Goldblatt
- Film Editing
- Andrew Lockington
- Original Music
- Claude Paré
- Production Design
- Helen Jarvis
- Supervising Art Direction
- Dan Hermansen
- Art Director
- Kirsten Franson
- Art Director
- Shane Vieau
- Set Decoration
- Monique Prudhomme
- Costume Design
- Alyssa Weisberg
- Casting
- Coreen Mayrs
- Casting
- Heike Brandstatter
- Casting
