- Paul and his Mad About You (1992) co-star, Helen Hunt, were each given $1,000,000 per episode for the 1999 season.
- Received his Bachelor's degree from Binghamton University, where he majored in music (piano and composition).
- Recently reunited with Helen Hunt for a Mad About You (1992) reunion. (January 2005)
- Named his production company, Nuance Productions, after a speech his character gives in the comedy movie Diner (1982).
- Began his career as a stand-up comedian.
- Is of Romanian Jewish ancestry.
- Currently resides with his family in Los Angeles, California.
- Has two sons: Ezra Samuel Reiser (born 1995) and Leon Reiser (born 2000).
- During his university years, Paul was active in student theater productions at the Hinman Little Theater, an on-campus community theater organization located in Hinman College, his dorm community. This was later renamed the Hinman Production Company.
- Best-known by the public for his role as Carter Burke in James Cameron's science-fiction epic Aliens (1986), as well as his starring roles as Michael Taylor in My Two Dads (1987) and as Paul Buchman in Mad About You (1992).
- Attended and graduated from Stuyvesant High School in New York City (1973).
- Parents are Sam and Helen Reiser.
- Friends with John Ritter.
- Was invited to join the actor's branch of the Academy of Motion Picture Arts & Sciences in 2023.
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