During the chase scene in the super market, the Terminator theme song could be heard and a character is seen running like the T-1000. In addition to being an NBC Universal IP, The Despicable Me ride took over the building from the Terminator ride at Universal Studios Hollywood.
Miranda Cosgrove was 17 when she voiced Margo in the first film. By the time of the fourth film, she was 31 when the movie entered production.
The name of Gru's alma mater is Lycee Pas Bon. Translating from French to English, the name is High School- No Good.
When Gru and his family break into the castle, the plaque on the desk reads Principal Übel Schlecht. This translate literally as "Principal Bad Bad".