Nevro reposted this
The latest insights on kHz SCS from Nevro’s Scientific Research team was just published in Biomedicines https://lnkd.in/gqFMKMNe . This work, "Frequency-Dependent Neural Modulation of Dorsal Horn Neurons by Kilohertz Spinal Cord Stimulation in Rats," used Calcium imaging in an in vitro slice model to investigate neuronal activity at different depths of rodent dorsal horn in response to extracellular kHz spinal cord stimulation. The key observations are that the strength of the response is positively and monotonically correlated to frequency, in that the maximum effects were seen using 8 kHz – 10 kHz; these responses were approximately 2-fold those seen at 1 kHz. This higher kHz frequency dominance was also observed at deeper dorsal horn regions. Finally, and perhaps most interestingly, individual neurons appeared to have a particular frequency which maximized their Calcium fluorescent response; in fact, 8 kHz was the optimal frequency for a substantial number of neurons (25-40% of population). This seminal work may improve how high kHz frequency is applied clinically. Congratulations to the team of Dong Wang, who played a key role in the conceptualization of the experiments and manuscripts and is a leading researcher in kHz stimulation; Kwan Yeop Lee, who has visionarily conceived and performed the core experiments providing the base understanding of direct & selective activation of inhibitory neurons in the dorsal horn via low-intensity kHz SCS; Dongchul Lee, a pioneer in SCS computational modeling and broad- and deep-thinking leader of exploratory work studying mechanisms of kHz stimulation, and Zack Kagan, a critical and analytical contributor to studies of kHz SCS, as well as a key clinical and educational liaison, fostering translation from animal-to-bedside and communication with physicians of the merits and mechanisms of kHz SCS.