#SNMMI24 presentation recap: Mathematical Modeling of Exposure Measurements Following High-Dose Targeted Therapy Using 131I-apamistamab: Analysis From the Large Multicenter Phase III SIERRA Trial. Details: https://bit.ly/3Rpk8vV
Actinium Pharmaceuticals, Inc.’s Post
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Nice to see a PBPK modelling study we assisted with published. We wrote a LUA script to describe the rotamer interconversion kinetics in the luminal fluids exploiting the luminal metabolism (parent-metabolite two way interconversion) framework available in Simcyp. This model framework can be used for prodrug conversion to parent, and to model metabolism by the gut microbiota including for example deglucuronidation of biliary cleared metabolite to parent, such that the parent can be reabsorbed from the gut.
PBPK Modeling of PAXLOVIDTM: Incorporating Rotamer Conversion Kinetics to Advanced Dissolution and Absorption Model https://lnkd.in/d49_8DmV
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Fluorescence is the base of countless lab applications, including enzymatic assays, identification of transformants, proteins detection via ELISA, and screening drug candidate libraries. Reshape Imaging System supports endpoint or continuous fluorescence readings for up to 10 microtiter plates or 15 petri dishes simultaneously! Pair that with automated analysis and achieve deeper insights of your research, boosting efficiency and throughput. Let's illuminate the future of your experiments together!
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💊 𝗔𝘁 𝗣𝗵𝗶𝗻𝗖 𝗗𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁, 𝘄𝗲 𝘂𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱 𝘁𝗵𝗮𝘁 𝘁𝗵𝗲 𝗔𝗗𝗠𝗘 𝗽𝗿𝗼𝗰𝗲𝘀𝘀 𝗶𝘀 𝗰𝗿𝘂𝗰𝗶𝗮𝗹 𝗶𝗻 𝘆𝗼𝘂𝗿 𝗱𝗿𝘂𝗴 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁. This step determines how a drug is absorbed into the bloodstream, distributed to tissues, metabolized by the body, and ultimately eliminated. Through advanced modeling and simulation, particularly using #PBPK (Physiologically Based Pharmacokinetic) approaches, we can predict these processes with remarkable accuracy. By considering the physicochemical properties of the drug, 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 biotransformation and transport data, and the anatomy and physiology of the human or animal body, our models facilitate dose optimization and regimen design. ➡ Learn how: https://lnkd.in/dSatNmtA
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Florescence - the northern lights of the lab world? From enzymatic assays to protein detection with ELISA and large drug candidate library screens, the Reshape Imaging System supports endpoint or continuous fluorescence readings for up to 10 microtiter plates or 15 petri dishes simultaneously! Pair that with our automated analysis and achieve deeper insights into your research, boosting efficiency and throughput. Let's illuminate the future of experiments together!
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How do we meet the growing demand for novel mAbs? With robust and high-throughput methods for screening and characterization. See how advanced flow cytometry can support workflows with rapid, multiplexed analysis. View here: https://ow.ly/9vhT50PqFLw #flowcytometry #antibody
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Today's interesting read for me was this paper combining DESI XS and Ion mobility on the Cyclic IMS in MS Imaging - making efficient use of very limited sample per pixel for enhancing spatial lipidomics with the resolution of isobaric lipids. https://lnkd.in/e-26Gzk3
Mobility‐Modulated Sequential Dissociation Analysis Enables Structural Lipidomics in Mass Spectrometry Imaging
onlinelibrary.wiley.com
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Single Cell Omni Omics is taking single-cell analysis to the next level. 🚀 Come see us at #ASMS2024 to learn how this MALDI-MS platform enables sequential analyte detection from the same cells. #SingleCell #omics
Seeing is believing. Coming to ASMS, Single Cell Omni Omics, a true single cell platform that uses sequential analyte detection by MALDI MS. Individual cells are captured, prepped for analyte, visualized, selected, and lasered. Thousands of single cells can be analyzed in minutes. The same cells can be re-prepped for a different analyte, then detected, and repeat. Developed in Anand Mehta laboratory at the Medical University of South Carolina by Jake Dressman and Furkan Bayram , the platform will be presented by Jake on Sunday at the Bruker eXceed symposia, and the software and targeting components by Furkan at the Mass Spectrometry Imaging Workshop on Wednesday afternoon. #glycotime #gogoglycans #IMSIS #spatialbiology #ASMS2024
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#Organonachip models can better replicate the complex microenvironment and interactions of cells within an organ compared to traditional 2D cell cultures. Workflows using these models can be automated, allowing you to increase throughput, decrease the risk of human error, and ultimately obtain better data faster. In this poster, we demonstrate an integrated workflow that incorporates automated cell seeding, media exchange, compound testing and imaging. https://ow.ly/6N1u50PGpMH
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Democratizing Nani-DESI mass spectrometry imaging experiments using triple quad. Cost effective, sensitive, quantitative platform that enables targeted imaging of tens of analytes in the same experiment, separation of closely-spaced isobars, and isomers. Congrats to Miranda Weigand on the first-author paper and to all the co-authors on the publication (Daisy Unsihuay , Manxi Yang , Hang Hu , Emerson Hernly , Matthew Muhoberac , Shane Tichy ) https://lnkd.in/grDUREEM
Lipid Isobar and Isomer Imaging Using Nanospray Desorption Electrospray Ionization Combined with Triple Quadrupole Mass Spectrometry
pubs.acs.org
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Diving into the mesmerizing world of microfluidics, where tiny channels lead to groundbreaking discoveries. Exploring the endless possibilities at the intersection of science and precision engineering. Learn more about the partnership between NYtor and Micronit that is changing the field of molecular diagnostics in the carousel below. #microfluidics #micronit #nytor #diagnostic
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