HCPToday��s Post

I'm excited to share that our new paper titled "Clinical Utility of Diffusion MRI-Derived Measures of Cortical Microstructure in a Real-World Memory Clinic Setting" has been published in Annals of Clinical and Translational Neurology. This study explores how advanced diffusion MRI can be applied in clinical settings to assess cortical microstructural alterations, potentially improving diagnostic strategies for neurodegenerative disorders. A special thanks to Andrea Arighi and all the co-authors for their hard work and dedication. You can read the full paper here: https://lnkd.in/dACWh6SV #MRI #DIFFUSION MRI #alzheimersdisease #cortex #Dementia #neuroimaging #brain #neurodegeneration #AlzheimersResearch #biomarkers #neuroscience #corticaldiffusivity #ENDALZ #diagnostics

In a phase 1 clinical trial led by Weill Cornell Medicine, Stanford University, Cleveland Clinic, Harvard Medical School, and the University of Utah, deep brain stimulation (DBS) showed significant promise in improving cognition and quality of life for individuals with lasting cognitive deficits from traumatic brain injuries (TBIs). Administered for 12 hours daily targeting the thalamus, the DBS resulted in 15-55% improvements in executive functions after three months of treatment. The successful trial opens the door for larger clinical trials, suggesting that DBS may be a potential treatment for cognitive deficits associated with TBIs, even years after the injury. #BrainInjury #DeepBrainStimulation #Neuroscience

In a recent episode, Dr. Gary Steinberg, a renowned neurosurgeon and professor at Stanford University School of Medicine, delves into critical aspects of brain health and injuries. The discussion spans various conditions including concussions, traumatic brain injury (TBI), stroke, aneurysms, and transient ischemic attacks (TIA). Dr. Steinberg sheds light on both common and lesser-known risk factors affecting brain health. He discusses current treatments and medications that have the potential to enhance cognitive function. Notably, the episode explores innovative recovery mechanisms such as stem cell therapy, mild hypothermia, and vagus nerve stimulation. In addition, Dr. Steinberg highlights significant advances in neurosurgery and minimally invasive brain augmentation techniques. This episode is particularly insightful for individuals aiming to improve brain health and those recovering from brain injuries. #BrainHealth #Neurosurgery #CognitiveFunction #InnovationInMedicine #RecoveryTechniques ---------------------- Learn more here: https://lnkd.in/eMm-yhvS

NeuroOne Medical Technologies Corporation (NASDAQ: NMTC) has received FDA clearance for its OneRF system, an advancement of its stereoelectroencephalography (sEEG) electrode. The sEEG electrode, designed for diagnosing neurological conditions, can now also be used therapeutically. The OneRF system utilizes a single sEEG electrode beneath the brain's surface to monitor and treat conditions like epilepsy and Parkinson's disease. The system's dual functionality enables it to map brain signals for diagnosis and perform radiofrequency ablation, providing doctors with more control over tissue destruction. This clearance represents a milestone for NeuroOne, aligning with the company's long-standing goal of commercializing a combined diagnostic and therapeutic electrode to improve patient outcomes. CEO, Dave Rosa, anticipates positive impacts, including reduced hospital stays and enhanced patient safety. For more information please find the attached article: https://lnkd.in/eA5R_fDv #neuroscience #neurology #epilepsy #epilepsyawareness #parkinsonsdisease

Newest publication from #DubravaUniversityHospital #neurosurgery team🌞 Our paper was the firt one to investigate the association of brain and brain compartment volumes on MRI using both qualitative and quantitative analysis with the occurrence of PLE in PD patients after STN DBS. The results of our study suggest that the morphometric MRI measurements, as a useful tool, can provide relevant information about the structural status of the brain in patients with PD and represent moderate indicators of possible PLE occurrence. Identifying patients with greater brain atrophy, especially regarding grey matter before DBS implantation, will allow us to estimate the possible postoperative symptoms and intervene in a timely manner. Many thanks to co-authors! 😊 #dbs #parkinsonsdisease #perileadedema #mri #mristudies #stereotacticandfunctionalneurosurgery #neurosurgery #education https://lnkd.in/dm_qsKyW

Revolutionizing Brain Disorder Treatments: The Potential of Non-Invasive Ultrasound Stimulation Explore the groundbreaking research led by Dr. PARK Joo Min on the innovative LILFUS technique, revolutionizing neurological treatment with its precise and safe brain stimulation methods. https://lnkd.in/d-tvcQXa #braindisorder #ultrasoundtechnology #neurological #brainstimulation

🧠 New study by Arrigoni et al. assesses the impact of COVID-19 on brain structure, microstructure, and connectivity in patients with either cognitive impairments or olfactory disorders using multi-directional diffusion-weighted MRI (DW-MRI). It reveals notable changes in brain connectivity and tissue properties, reflecting the neural impact of COVID-19. 🔬 Study Design: The methodology includes a robust DW-MRI processing pipeline for analyzing brain microstructure and connectivity, complemented by T1-weighted scans for precise brain parcellation. 💡 Key Findings: 🕐 There was significant gray matter atrophy in COVID-19 patients with cognitive impairment, specifically marked by increased mean diffusivity and decreased fractional anisotropy in white matter regions (p = 0.004 for atrophy, p < 0.05 for diffusion metrics). 🕑 Graph-based analysis showed decreased network modularity and changes in network efficiency, indicating disrupted brain network integrity and increased compensatory connectivity (modularity p < 0.05). 🕒 Fixel-based analysis highlighted localized white matter damage, particularly in the corpus callosum and associated connectivity pathways, potentially underlying observed cognitive and sensory deficits (p < 0.05 for fiber density and cross-section changes). 🕓 The study found specific regions, including the left insula and cingulate cortex, that exhibited both significant structural alterations and connectivity disruptions, suggesting focal points for neuro-COVID manifestations. For more details: https://lnkd.in/dgd74nWZ #Neuroimaging #COVID19 #Neurology #BrainConnectivity

Cleveland Clinic's recent first-in-human deep brain stimulation (DBS) trial for post-stroke rehabilitation has shown promising results. The EDEN trial targeted the dentate nucleus in the brain and found DBS to be safe and feasible. Key findings include: Nine out of 12 participants demonstrated improvements in motor impairment and function. Participants with minimal preservation of distal motor function at enrollment nearly tripled their initial scores. No significant complications were reported throughout the study. Published in Nature Medicine, this study opens doors for potential improvements in chronic phases of stroke recovery. The quality-of-life implications for those who responded to therapy are significant, and the results support the need for additional, more extensive trials. Stroke affects approximately 800,000 people in the U.S. annually, and this research offers hope for enhancing rehabilitation outcomes. https://lnkd.in/g5YMa5S9 #stroke #rehabilitation #deepbrainstimulation #neurology #medicalresearch #acapedia

Original Research Share from Journal of Integrative Neuroscience 🎺 Aberrant White Matter Development in Cerebral Visual Impairment: A Proposed Mechanism for Visual Dysfunction Following Early Brain Injury 🖲 https://lnkd.in/gnb4qTna ✒ By Dr. Corinna M. Bauer and Dr. Lotfi Merabet 📩 Any Questions: Amy.wang@imrpress.com 🌟 #cerebralvisualimpairment #corticalvisualimpairment #tractography #neuroscience Background: Cerebral visual impairment (CVI) is a common sequala of early brain injury, damage, or malformation and is one of the leading individual causes of visual dysfunction in pediatric populations worldwide. Although patients with CVI are heterogeneous both in terms of underlying etiology and visual behavioural manifestations, there may be underlying similarities in terms of which white matter pathways are potentially altered. This exploratory study used diffusion tractography to examine potential differences in volume, quantitative anisotropy (QA), as well as mean, axial, and radial diffusivities (mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD), respectively) focusing on the dorsal and ventral visual stream pathways in a cohort of young adults with CVI compared to typically sighted and developing controls.

By studying 371 individuals with #AD neuropathology and mild cognitive impairment, researchers identified several factors associated with cognitive and brain resilience to #tau pathology. 🧠 The full paper by Diana I. Bocancea, Anna L. Svenningsson, Anna C. van Loenhoud, Colin Grout, Frederik Barkhof, Olof Strandberg, Ruben Smith, Renaud La Joie, Howard Rosen, Michael Pontecorvo, Gil D. Rabinovici, Wiesje van der Flier, Oskar Hansson, Rik Ossenkoppele, and the Alzheimer's Disease Neuroimaging Iniative is available in #Brain. ⬇️ https://lnkd.in/gBDn6URK Vrije Universiteit Amsterdam (VU Amsterdam) Lund University Skånes universitetssjukhus (Skåne University Hospital) Amsterdam UMC - Amsterdam Neuroscience UCL University of California, San Francisco Avid Radiopharmaceuticals #alzheimers #neuroimaging #longitudinal #cognition #PET #MRI #inhuman #neuroscience #neurology #basicresearch #nonanimalmethods #humanrelevantresearch #neurodegenerativedisease #alzheimersdisease