Developmental Biology Program
The Junhong Choi Lab
Research
The Choi Lab develops new synthetic biology tools to study cell-fate decisions in development. During development, cells differentiate into various cell types with distinct functions. To understand how different cell types are made, we need a tool to observe cells’ previous and current states, as well as the sequence of events they undergo. We focus on developing such new tools through:
- Cellular engineering
- Molecular circuitry
- DNA as an information storage medium, and
- Synthetic models for cellular development
These novel tools will provide new insights into understanding cell-fate decisions and facilitate cellular engineering for future therapy.
Research Projects
Publications Highlights
Junhong Choi#, Wei Chen, Anna Minkina, Florence M. Chardon, Chase C. Suiter, Samuel G. Regalado, Silvia Domcke, Nobuhiko Hamazaki, Choli Lee, Beth Martin, Riza M. Daza, Jay Shendure#. “A time-resolved, multi-symbol molecular recorder via sequential genome editing” Nature 608, 98-107 (2022)
Wei Chen*,#, Junhong Choi*, Jenny F. Nathans, Vikram Agarwal, Beth Martin, Eva Nichols, Anh Leith, Choli Lee, Jay Shendure#. “Multiplex genomic recording of enhancer and signal transduction activity in mammalian cells” bioRxiv (preprint) (2021)
Junhong Choi#, Wei Chen, Hanna Liao, Xiaoyi Li, Jay Shendure#. “A molecular proximity sensor based on an engineered, dual-component guide RNA” bioRxiv (preprint) (2023)
Junhong Choi*,#, Wei Chen*, Chase C. Suiter, Choli Lee, Florence M. Chardon, Wei Yang, Anh Leith, Riza M. Daza, Beth Martin, Jay Shendure#. “Precise genome deletions using paired prime editing” Nature Biotechnology 40, 218-226 (2021)
Xiaoyi Li, Wei Chen, Beth K. Martin, Diego Calderon, Choli Lee, Junhong Choi, Florence M. Chardon, Troy McDiarmid, Haedong Kim, Jean-Benoit Lalanne, Jenny F. Nathans, Jay Shendure. “Chromatin context-dependent regulation and epigenetic manipulation of prime editing” bioRxiv (preprint) (2023)
People
Junhong Choi, PhD
Assistant Professor
- The Choi Lab develops new synthetic biology tools to study cell-fate decisions in development.
- PhD, Stanford University
- [email protected]
- Email Address
Members
Lab Affiliations
Achievements
- Damon Runyon-Dale F. Frey Award for Breakthrough Scientists (2024-2026)
- K99/R00 Pathway to Independence Award (2023-2027)
- Damon Runyon Cancer Research Fellowship (2020-2023)
- Stanford Bio-X Graduate Fellowship (2015-2018)
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
General Opportunities
We are actively recruiting research scientists, postdoctoral fellows, and graduate students who are interested in synthetic biology, stem-cell biology, single-cell genomics, and developmental biology.
Get in Touch
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Lab Head Email