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AP

CLEVELAND (AP) β€” David Price struck out 10 and won his weather-delayed debut for Boston, and David Ortiz hit a two-run homer Tuesday to lead the Red Sox to a 6-2 win over the Cleveland Indians, who pushed back their season opener a day because of wintry conditions.

Price (1-0) gave up two runs and five hits in six innings, giving the Red Sox an immediate payoff after they signed the left-hander to a $217 million, seven-year contract.

Ortiz began his farewell season with a bang, connecting for his 504th homer in the ninth. Big Papi tied Hall of Famer Eddie Murray for 26th place on the career list. Ortiz also doubled.

Boston's Mookie Betts homered in the second off Corey Kluber (0-1), tagged with a loss in the opener for the second straight year. Cleveland's ace gave up four runs and nine hits in 5 1-3 innings.

Price improved to 10-2 with a 2.24 ERA in 14 starts against Cleveland.

Boston's win was also meaningful to manager John Farrell, who left the club last season after he was diagnosed with cancer.

The Red Sox broke a 2-all tie in the sixth on Brock Holt's RBI single and Kluber's wild pitch.

RAYS 3, BLUE JAYS 2

ST. PETERSBURG, Fla. (AP) β€” Baseball's new rule on breaking up double plays gave Logan Forsythe and Tampa Bay a disputed victory over Toronto.

With the bases loaded and one out in the ninth inning, Toronto slugger Edwin Encarnacion hit a grounder to third. After taking a throw from Evan Longoria for the force at second, Forsythe made an errant relay to first that appeared to allow the go-ahead run to score for the Blue Jays.

Rays manager Kevin Cash asked for a replay review, claiming Jose Bautista violated the new "Chase Utley Rule" governing slides on potential double plays.

Replay umpires in New York ruled Bautista's slide was not directly into the bag and it illegally hindered Forsythe. The call was changed to a game-ending double play that preserved Tampa Bay's victory.

Blue Jays manager John Gibbons argued with umpires on the field before finally heading toward the clubhouse.

Forsythe hit a two-run homer in the eighth off Brett Cecil (0-1) that ended the reliever's run of 38 straight appearances without allowing an earned run, dating to June 24. The left-hander's stretch was tied with Craig Kimbrel (2011 with Atlanta) for the longest in the majors since earned runs became an official stat in 1912 in the National League and one year later in the American League.

Corey Dickerson also homered for the Rays. Alex Colome (1-0) went the final two innings to get the win.

ASTROS 5, YANKEES 3

NEW YORK (AP) β€” A freezing opening day at Yankee Stadium turned on a play that caused a hot argument.

Carlos Correa reached on an eighth-inning dribbler that Dellin Betances threw over first baseman Mark Teixeira as Jose Altuve scored the tiebreaking run, and Houston beat New York to win four straight openers for the first time in franchise history.

Yankees manager Joe Girardi argued with plate umpire Dana DeMuth that Correa should have been called out for running on the fair side of the foul line, causing Betances (0-1) to throw the ball over Teixeira for an error.

After the four umpires conferred, the call was upheld and Girardi played the remainder of the game under protest. Luis Valbuena added a two-run single on Betances' 30th and final pitch for a 5-2 lead.

Dallas Keuchel dominated, but not quite as much as in last October's AL wild-card game. Keuchel (1-0) allowed Starlin Castro's two-run double in the second, which ended the AL Cy Young Award winner's 29-inning scoreless streak against New York. The left-hander gave up three hits in seven innings.

Correa also homered off Masahiro Tanaka and drove in two runs.

Didi Gregorius homered in the eighth off new Astros reliever Ken Giles. Luke Gregerson got three straight outs for a save.

The temperature was 36 degrees at game time, the coldest for a regular-season Yankees game in the Bronx since their 2003 home opener.

METS 2, ROYALS 0

KANSAS CITY, Mo. (AP) β€” Noah Syndergaard pitched six dominant innings, Neil Walker hit his first homer with the Mets and New York beat Kansas City after the Royals were given their 2015 World Series rings.

Syndergaard (1-0) was the only pitcher to beat the Royals in the World Series last year, winning Game 3 after intentionally throwing his first pitch above Alcides Escobar's head, which angered the Royals.

Escobar started this one with a triple, but then Syndergaard struck out the next three batters and retired 12 straight before Kendrys Morales' double opened the fifth.

Syndergaard allowed three hits, walked one and struck out nine. He pitched out of a bases-loaded jam in the sixth, striking out Morales on three swings. The Royals, who held on to beat New York 4-3 in their season opener Sunday night, went 0 for 7 with runners in scoring position.

Walker, acquired in a December trade with Pittsburgh, homered off Chris Young (0-1) in the fourth after Yoenis Cespedes walked.

Jeurys Familia, saddled with three blown saves in the 2015 World Series, pitched a spotless ninth for his first save this season.

PIRATES 6, CARDINALS 5, 11 INNINGS

PITTSBURGH (AP) β€” Jordy Mercer singled home Gregory Polanco from second base with one out in the 11th inning to lift Pittsburgh over St. Louis.

Polanco, who agreed to a $35 million, five-year contract earlier in the day, drew a walk from Seth Maness (0-1) and made it to second on Josh Harrison's infield single. Mercer slapped a single to right for his fourth career game-ending hit.

Kyle Lobstein (1-0) pitched two innings for the win, and Andrew McCutchen had three hits for the Pirates.

Jedd Gyorko hit his first home run for St. Louis, and Stephen Piscotty had two RBIs.

Cardinals relievers retired 18 straight batters before Polanco's walk started the winning rally.

GIANTS 2, BREWERS 1

MILWAUKEE (AP) β€” Johnny Cueto pitched seven solid innings to win his San Francisco debut against Milwaukee.

Cueto (1-0) was the centerpiece of the Giants' offseason rotation overhaul when he signed a $130 million, six-year deal after winning a championship with Kansas City. The right-hander scattered six hits and struck out four, winning his seventh straight against Milwaukee.

Brandon Crawford homered for the Giants and saved a run with a sharp defensive play at shortstop. Santiago Casilla got three outs for his first save.

Brewers starter Jimmy Nelson (0-1) took the hard-luck loss.

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