San Francisco 49ers schedule for the 2021 NFL season

USA TODAY

Here is a week-by-week look at the 2021 NFL schedule for the San Francisco 49ers:

Sept. 12 - at Detroit Lions, 1 p.m. ET (FOX)

Sept. 19 - at Philadelphia Eagles, 1 p.m. ET (FOX)

Sept. 26 - Green Bay Packers, 8:20 p.m. ET (NBC)

Oct. 3 - Seattle Seahawks, 4:05 p.m. ET (FOX)

All things 49ers: Latest San Francisco 49ers news, schedule, roster, stats, injury updates and more.

Oct. 10 - at Arizona Cardinals, 4:25 p.m. ET (FOX)

Oct. 24 - Indianapolis Colts, 8:20 p.m. ET (NBC)

Oct. 31 - at Chicago Bears, 1 p.m. ET (FOX)

Nov. 7 - Arizona Cardinals, 4:25 p.m. ET (FOX)

Nov. 15 - Los Angeles Rams (Monday), 8:15 p.m. ET (ESPN)

Nov. 21 - at Jacksonville Jaguars, 1 p.m. ET (FOX)

Nov. 28 - Minnesota Vikings, 4:25 p.m. ET (FOX)

Dec. 5 - at Seattle Seahawks, 8:20 p.m. ET (NBC)

Dec. 12 - at Cincinnati Bengals, 1 p.m. ET (CBS)

Dec. 19 - Atlanta Falcons, 4:05 p.m. ET (CBS)

Dec. 23 - at Tennessee Titans (Thursday), 8:20 p.m. ET (NFLN)

Jan. 2 - Houston Texans, 4:05 p.m. ET (CBS)

Jan. 9 - at Los Angeles Rams, 4:25 p.m. ET (FOX)

Featured Weekly Ad