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MLB

San Diego Padres at Chicago Cubs odds, picks and prediction

Jess Root
Sportsbook Wire

The San Diego Padres (34-22) and Chicago Cubs (31-23) wrap up their three-game series Wednesday afternoon at 2:20 p.m. ET at Wrigley Field. Let's analyze BetMGM Sportsbook's lines around the Padres vs. Cubs odds with MLB picks and predictions.

RHP Dinelson Lamet is the projected starting pitcher for the Padres. He is 1-0 with a 2.57 ERA, 1.50 WHIP, 9.6 K/9 and 3.9 BB/9 through 14 IP over 4 starts and two relief appearances.

Lamet has not pitched more than 3 innings in a start this season. He is 1-1 with a 4.50 ERA against the Cubs in his career but is making his first-ever appearance at Wrigley Field.

RHP Adbert Alzolay is the projected starting pitcher for the Cubs. He is 3-4 with a 3.81 ERA, 0.93 WHIP, 9.2 K/9 and 1.8 BB/9 in 49 2/3 IP over 9 starts.

This will be Alzolay's first career start against the Padres. He struck out at least 6 batters in seven of his nine starts this season.

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Padres at Cubs odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 10:20 a.m. ET.

  • Money line : Padres +100 (bet $100 to win $100) | Cubs -120 (bet $120 to win $100)
  • Against the spread/ATS : Padres +1.5 (-200) | Cubs -1.5 (+165)
  • Over/Under : 7.5 (O: +100 | U: -120)

Prediction

Padres 5, Cubs 3

Money line (ML)

The Cubs are 20-10 at home this season and have two series sweeps at Wrigley Field.

The Padres have not been swept in a series on the road and have not lost more than three games in a row. They are riding a three-game skid at the moment.

Take the PADRES (+100).

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Run line/Against the spread (ATS)

Chicago is 30-24 ATS while San Diego is 31-25 ATS.

The Padres are 13-8 ATS after a loss and the Cubs are 14-16 ATS following a win.

The Padres are 8-4 ATS as underdogs. The Cubs are 12-17 ATS as favorites.

Take the PADRES +1.5 (-200).

Over/Under (O/U)

The first two games of the series went Under the projected total but the line for Wednesday's game is the lowest of the series. The Cubs are 21-30-3 O/U this season.

The Padres are 29-27 O/U and 18-10 O/U on the road. Lamet's last two starts saw totals of 10 and 13 runs.

With a lower total than the first two games of the series, take OVER 7.5 (+100).

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