Houston Astros at Boston Red Sox odds, picks and prediction

The Houston Astros (35-26) go for a three-game sweep of the Boston Red Sox (37-25) Thursday at Fenway Park. First pitch is slated for 7:10 p.m. ET (on MLB Network). Let's analyze BetMGM Sportsbook's lines around the Astros vs. Red Sox odds with MLB picks and predictions.

Season series: Astros lead 5-1

Houston took the first two games of this series by scores of 7-1 Tuesday and 8-3 Wednesday.

RHP Zack Greinke is projected to start the finale for the Astros. He is 6-2 with a 3.38 ERA (82 2/3 IP, 31 ER), 1.09 WHIP, 6.5 K/9 and 1.7 BB/9 over 13 starts this season.

• Last outing: Complete-game win, 9 IP, 1 ER, 6 H, 1 BB, 3 K in Houston's 13-1 victory vs. Toronto Blue Jays in Buffalo, N.Y., Friday
• Career vs. Red Sox: 2-5, 4.60 ERA (43 IP, 22 ER), 1.44 WHIP, 6.9 K/9 in 7 starts and 1 relief appearance

Follow every MLB game: Latest MLB scores, stats, schedules and standings.

LHP Eduardo Rodriguez is projected to toe the hill for the Red Sox. He is 5-4 with a 5.59 ERA (58 IP, 36 ER), 1.41 WHIP, 10.1 K/9 and 2.2 BB/9 across 11 starts.

• Last outing: No-decision, 5 1/3 IP, 3 ER, 5 H, 1 BB, 7 K at New York Yankees Saturday - Red Sox won 7-3
• Career vs. Astros (regular season): 1-3, 7.84 ERA (20 2/3 IP, 18 ER), 1.89 WHIP, 10.0 K/9 in 5 starts

MLB betting offers/promotions

BetMGM Sportsbook offers available in CO, IA, IN, MI, NJ, PA, TN, VA and WV. New customer offers, terms and conditions apply.

• Bet just $1 on either team's money line, WIN $100 (in free bets) if either team hits a home run during the game. Bet now!
• RISK-FREE FIRST BET. Place your first bet, if it loses you'll get up to $600 in free bets.Bet now!

Astros at Red Sox odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 6:35 a.m. ET.

• Money line : Astros -115 (bet $115 to win $100) | Red Sox -105 (bet $105 to win $100)
• Against the spread/ATS : Astros -1.5 (+135) | Red Sox +1.5 (-160)
• Over/Under : 9 (O: -110 | U: -110)

Prediction

Astros 6, Red Sox 2

Money line (ML)

The ASTROS (-115) are the STRONGEST PLAY - 1½ times your usual wager - due to a big advantage in the pitching matchup.

Greinke has struggled against the Red Sox in his career, but he is coming off a complete-game victory and is 3-1 with a 2.03 ERA (31 IP, 7 ER) in his last four starts.

Rodriguez is 0-3 with an 8.53 ERA (19 IP, 18 ER) in his last four starts, including a loss at Houston when he yielded 6 earned runs over 4 2/3 innings.

FANTASY BASEBALL: Serious about winning your league? Sign up for BaseballHQ.com to dominate the competition.Subscribe now!

Run line/Against the spread (ATS)

Back the ASTROS -1.5 (+135) with a HALF-UNIT wager. Houston covered the spread in the first two games of this series, and Greinke's last four wins were each by at least 3 runs.

ATS records: Astros 31-30 | Red Sox 36-26

Over/Under (O/U)

UNDER 9 (-110) is worth a QUARTER-UNIT bet. The O/U is 1-1 in this series and 2-4 in their six head-to-head meetings in 2021.

AVOID if the line drops below 9.

O/U records: Astros 36-23-2 | Red Sox 28-33-1

PLAY: Free, daily sports pick'em contests.Play now!

Bet on this game now atBetMGM Sportsbook. For more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.

Follow @JohnnyParlay11 on Twitter.Follow SportsbookWire on Twitter and like us on Facebook.

Gannett may earn revenue from audience referrals to betting services. Newsrooms are independent of this relationship and there is no influence on news coverage. This information is for entertainment purposes only. We make no representations or warranties as to the accuracy, completeness, or reliability of any content.