USC at Colorado odds, picks and prediction

The USC Trojans (2-2, 1-2 Pac-12) and Colorado Buffaloes (1-3, 0-1) meet Saturday at Folsom Field in Boulder, Colo. Kickoff is scheduled for 2 p.m. ET. Below, we look at the USC vs. Colorado odds and lines, and make our expert college football picks, predictions and bets.

The Trojans have alternated wins and losses, as well as covers against the spread, in their four outings this season. USC also hit the Under in each of its two wins, allowing just 10.5 points per game (PPG), while hitting the Over in each of the two losses, yielding 43.5 PPG.

The Buffaloes have dropped three straight games, and they're having a power outage lately. After posting a 35-7 win over FCS Northern Colorado Sept. 3, Colorado has scored a total of just 20 points in the past three games. The Under is 3-1 for the Buffaloes.

USC at Colorado odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports' betting odds for a full list. Lines last updated at 7:14 a.m. ET.

• Money line: USC -360 (bet $360 to win $100) | Colorado +270 (bet $100 to win $270)
• Against the spread (ATS): USC -9.5 (-108) | Colorado +9.5 (-112)
• Over/Under (O/U): 50.5 (O: -115 | U: -107)

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USC at Colorado odds, lines, picks and predictions

Prediction

USC 26, Colorado 13

Money line

USC (-360) is the far more talented team, especially on the offensive side of the football, but it cannot be trusted risking more than three and a half times your potential return.

AVOID and look to the spread instead.

Against the spread

USC -9.5 (-108) is the play, even on the road, as the Trojans at least have a functional offense. Colorado has struggled on offense, posting just 239.0 total yards per game and 85.0 passing yards per game, ranking 128th out of 130 teams in both categories. It ranks 127th, scoring just 13.8 PPG.

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Over/Under

UNDER 50.5 (-107) is a great play here as the USC offense has been a bit disjointed, while we touched on the struggles of Colorado above. The Buffs defense has been stout, too, allowing just 20.5 PPG.

The Under is 7-3 across the past 10 games overall for USC dating back to last season. While the Over is 5-1 across the past six Pac-12 tilts for Colorado, again, it has managed just 20 total points of offense in the past three games.

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