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First look: LSU at Ole Miss odds and lines

Joe Williams
Sportsbook Wire

The LSU Tigers (4-3, 2-2 SEC) meet the No. 12 Ole Miss Rebels (5-1, 2-1) Saturday at Vaught-Hemingway Stadium in Oxford, Miss. Kickoff is scheduled for 3:30 p.m. ET. Below, we look at the LSU vs. Ole Miss odds and lines; check back for our college football picks and predictions.

The Tigers outlasted Florida 49-42 to win outright as 12.5-point underdogs in Death Valley as the Over landed. In fact, it was the highest-scoring game in the history of the series. The win snapped a two-game loss and non-cover skid.

The Rebels dodged the Tennessee Volunteers, golf balls, mustard bottles and beer cans for a 31-26 victory in Knoxville Saturday night. Ole Miss improved to 3-2-1 ATS. The 31 points were actually a season-low in production in a victory.

Rankings according to the AFCA Coaches Poll powered by USA TODAY Sports.

LSU at Ole Miss odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports' betting odds for a full list. Lines last updated Monday at 11:30 a.m. ET.

  • Money line: LSU +280 (bet $100 to win $280) | Ole Miss -370 (bet $370 to win $100)
  • Against the spread (ATS): LSU +10.5, -108 (bet $108 to win $100) | Ole Miss -10.5, -112 (bet $112 to win $100)
  • Over/Under (O/U): 76.5, O: -108 (bet $108 to win $100) | U: -112 (bet $112 to win $100)

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2021 betting stats:

  • ML: LSU 4-3 | Ole Miss 5-1
  • ATS : LSU 3-4 | Ole Miss 3-2-1
  • O/U : LSU 4-3 | Ole Miss 3-3

LSU at Ole Miss head-to-head

LSU leads the all-time series 64-40-4, and it has won five straight in this series. That includes a 53-48 win in Baton Rouge last year. LSU came away with a 58-37 win Nov. 16, 2019, last time these teams met in Oxford. Mississippi's last victory in the series came Nov. 21, 2015, a 38-17 pounding of LSU to set off a party in "The Grove".

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