Indianapolis Colts at San Francisco 49ers odds, picks and prediction
The Indianapolis Colts (2-4) will take on the rested San Francisco 49ers (2-3) on the road in the featured Sunday night game in Week 7. kickoff is 8:20 p.m. ET at Levi's Stadium. Below, we look at the Colts vs. 49ers odds and lines, and make our best NFL picks, predictions and bets.
The Colts, after losing their first three games of the season, have won two of their last three, and the one loss was in overtime against the Baltimore Ravens. They have scored at least 25 points in three straight games. QB Carson Wentz is heating up after dealing injuries to both ankles. He now has nine touchdown passes and only one interception this season, and RB Jonathan Taylor is averaging 5.4 yards per carry for 472 yards and four scores through six games.
The 49ers won their first two games of the season, only to drop their next three. They are coming off their bye week and get QB Jimmy Garoppolo back in the starting lineup after Trey Lance made his first NFL start in Week 5 in a 17-10 loss to the Arizona Cardinals.
Colts at 49ers odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports' betting odds for a full list. Lines last updated at 9:00 a.m. ET.
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- Money line: Colts +155 (bet $100 to win $155) | 49ers -190 (bet $190 to win $100)
- Against the spread (ATS): Colts +3.5 (-110) | 49ers -3.5 (-110)
- Over/Under (O/U): 42.5 (O: -112 | U: -108)
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Colts at 49ers key injuries
Colts
- OL Braden Smith (thumb, foot) out
- CB Rock Ya-Sin (ankle) out
- S Julian Blackmon (Achilles) out
- WR T.Y. Hilton (quad) questionable
49ers
- QB Trey Lance (knee) out
- DT Javon Kinlaw (knee) out
- LT Trent Williams (elbow, ankle) doubtful
- LB Marcell Harris (thumb) questionable
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Colts at 49ers odds, lines, predictions and picks
Prediction
49ers 27, Colts 21
Money line
The 49ers are just a different team with Garoppolo in the lineup. They are 24-10 in the regular season when he starts, and the one time he was healthy for a full season, he took them to the Super Bowl. Their defensive front will give Wentz problems.
Plus, coming off the bye, the 49ers have had extra time to prep and are playing at home, although they are 0-2 there this season.
Take the 49ERS (-190).
Against the spread
The Colts are 4-2 ATS this season, while the 49ers are 1-4 ATS. However, the 49ers are physical up front defensively, while the Colts will be missing one of their starting interior linemen, which will challenge the Colts' rushing attack.
The 49ers will apply pressure to Wentz and Garoppolo, if he doesn't get hurt again, keeps the 49ers offense on schedule.
Take the 49ERS -3.5 (-110).
Over/Under
With the Colts having scored 25 points or more in each of their last three games and the 49ers showing the ability to put points on the board - 41 against the Lions and 28 against the Packers, we can expect to see some points.
It won't be a shootout in the 30s, but we can expect both teams to be in the 20s this weekend. Take OVER 42.5 (-112).
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