NFL

Indianapolis Colts at Buffalo Bills odds, picks and prediction

Cameron DaSilva

Sportsbook Wire

The Indianapolis Colts (5-5) will take on one of the best teams in the AFC Sunday when they visit the Buffalo Bills (6-3). Seeking their third straight win, the Colts have their work cut out for them. Kickoff will be at 1 p.m. ET from Highmark Stadium. Below, we look at the Colts vs. Bills odds and lines, and make our best NFL picks, predictions and bets.

The Colts beat the Jets and Jags in their last two games, scoring a total of 68 points and allowing only 47. They've now won four of their last five games, scoring at least 23 points in each of those games. With their recent scoring outburst, the Colts now rank eighth in points and 12th in total yards.

The Bills have been surprisingly inconsistent despite boasting the best defense and second highest-scoring offense in the league. They lost to the Jaguars and Titans in the last four weeks, also beating the Dolphins and Jets convincingly.

Buffalo put up a season-high 489 yards against the Jets, though it did allow 366 yards to New York - their second-most allowed this season.

Colts at Bills odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports' betting odds for a full list. Lines last updated Saturday at 8:45 a.m. ET.

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Money line: Colts +265 (bet $100 to win $265) | Bills -350 (bet $350 to win $100)
Against the spread (ATS): Colts +7.5 (-117) | Bills -7.5 (-103)
Over/Under (O/U): 49.5 (O: -115 | U: -105)

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Colts at Bills key injuries

Colts

LB Darius Leonard (ankle) questionable

Bills

OL Spencer Brown (health and safety protocols) questionable
DT Star Lotulelei (health and safety protocols) questionable
LB Tremaine Edmunds (hamstring) questionable

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Colts at Bills odds, lines, predictions and picks

Prediction

Bills 27, Colts 20

Money line

It's hard to look past the Bills' 9-6 loss to the Jaguars two weeks ago because of just how stunning it was. However, I think it was an outlier and not at all representative of how good the Bills are.

So long as QB Josh Allen can avoid costly and ill-advised turnovers - which could be tough against the Colts, who have 21 takeaways this season - the Bills will win this game.

Take the BILLS (-350) to beat the Colts at home.

Against the spread

There are injuries on both sides, but the likely absence of Brown for the Bills could loom large because of how well the rookie has played this season.

The Colts will find a way to keep this one relatively close, as they have most of the season with a 6-4 ATS record.

Furthermore, the Colts are 4-2 ATS as underdogs, only failing to cover against the Seahawks and Titans in the first three weeks of the season.

BET the COLTS +7.5 (-103) to cover.

Over/Under

Both of these defenses are playing relatively well, particularly the Bills' defense. It's a big reason the total has only gone Over in four of their nine games this season.

In the last five meetings between these two teams, the Over is just 1-4, as well. The Bills' defense will force a couple of turnovers on QB Carson Wentz and also slow down RB Jonathan Taylor to limit the Colts' offense.

BET the UNDER 49.5 (-105).

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