First look: Indianapolis Colts at Arizona Cardinals odds and lines
The Indianapolis Colts (8-6) take a two-game winning streak on the road in Week 16 to face the Arizona Cardinals (10-4) Christmas night. Kickoff is set for 8:15 p.m. ET at State Farm Stadium. Below, we look at the Colts vs. Cardinals odds and lines; check back for our NFL picks and predictions.
The Colts have won five of their last six games and two in a row. They snapped the New England Patriots' seven-game winning streak with a 27-17 win Saturday. RB Jonathan Taylor rushed for 170 yards and a touchdown in the win. Taylor leads the NFL with 1,518 rushing yards and 17 rushing touchdowns.
The Cardinals have lost two in a row and three of five. They suffered their first road loss of the season Sunday in an embarrassing 30-12 loss to the Detroit Lions. The Cardinals were outgained 124 yards to 5 in the first quarter and fell behind 17-0. QB Kyler Murray has thrown three interceptions in his last two games.
Also see:All Week 16 odds and lines
Colts at Cardinals odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports' betting odds for a full list. Lines last updated Monday at 7:28 a.m. ET.
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- Money line: Colts +105 (bet $100 to win $105) | Cardinals -130 (bet $130 to win $100)
- Against the spread (ATS): Colts +2.5, -112 (bet $112 to win $100) | Cardinals -2.5, -108 (bet $108 to win $100)
- Over/Under (O/U): 48.5, O: -115 (bet $115 to win $100) | U: -105 (bet $105 to win $100)
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2021 betting stats:
- ML : Colts 8-6 | Cardinals 10-4
- ATS : Colts 9-5 | Cardinals 9-5
- O/U : Colts 8-6 | Cardinals 7-7
Colts at Cardinals head-to-head
The all-time series is tied 8-8 dating back to 1961.
Arizona has won the last two matchups. The last time they faced each other, the Cardinals picked up a 16-13 overtime win in 2017.
This will be Colts QB Carson Wentz's second career start against Arizona. It was in 2017 when he played for the Philadelphia Eagles and he led them to a 34-7 win. He threw for 304 yards and 4 touchdowns.
This will be Cardinals QB Kyler Murray's first career start against the Colts.
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