NFL

First look: Los Angeles Chargers at Kansas City Chiefs odds and lines

Wesley Roesch

Sportsbook Wire

The Kansas City Chiefs (1-0) return to GEHA Field at Arrowhead Stadium Thursday for their 1st home game of the season against AFC West rival the Los Angeles Chargers (1-0). Kickoff in Kansas City, Mo., is set for 8:15 p.m. ET (Prime Video). Below, we look at Chargers vs. Chiefs odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

The Chiefs dominated the Arizona Cardinals 44-21 in Week 1. QB Patrick Mahomes didn't miss a beat after losing star WR Tyreek Hill during the offseason, throwing for 360 yards and 5 TDs and spreading the ball around to 9 receivers. The Kansas City defense allowed just 7 points in the first 3 quarters, with both teams' backup QBs entering the game in the 4th.

The Chargers kicked off 2022 with a win over an AFC West rival as they beat the Las Vegas Raiders 24-19 in a nail-biter that saw the Raiders keep things close after being down 17-3 at halftime. Chargers QB Justin Herbert kept L.A. ahead with 279 yards and 3 TDs, also finding 9 receivers during the game.

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Chargers at Chiefs odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 2:19 p.m. ET.

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Money line (ML): Chargers +150 (bet $100 to win $150) | Chiefs -175 (bet $175 to win $100)
Against the spread (ATS): Chargers +3.5 (-112) | Chiefs -3.5 (-108)
Over/Under (O/U): 54.5 (O: -108 | U: -112)

Also see: All Week 2 odds and lines

2022 betting stats

ML : Chargers 1-0 | Chiefs 1-0
ATS : Chargers 1-0 | Chiefs 1-0
O/U : Chargers 0-1 | Chiefs 1-0

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Chargers vs. Chiefs head-to-head

The Chargers and Chiefs have a long-standing rivalry that dates to 1960. The Chiefs lead the all-time series 65-58-1 and are 5-2 against L.A. with Mahomes as the starting QB. Mahomes' career numbers against the Chargers: 1,827 yards, 16 TDs, 5 INTs plus 235 yards rushing.

Things have been a bit more even between these squads with Herbert in the mix. Herbert is 2-2 against K.C. since 2020, with 1,130 yards, 2 TDs, 2 INTs and 3 rushing TDs. Mahomes did not play in one of Herbert's wins in 2020. Nonetheless, L.A. is 3-1 ATS in its last 4 against the Chiefs.

The Chiefs and Chargers split the series 1-1 in 2021 in 2 close games. The Chargers won 30-24 as underdogs in September when WR Mike Williams dominated the K.C. secondary, earning 22 yards and 2 TDs. The Chiefs won 34-28 and covered the spread in the 2nd matchup in a December overtime thriller (also on a Thursday night). TE Travis Kelce was the Chiefs' leading man that night, notching 191 yards and 2 TDs.

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