San Francisco Giants at San Diego Padres odds, picks and predictions
The San Francisco Giants (2-1) and San Diego Padres (2-3) close out a 4-game series Sunday at Petco Park. First pitch is scheduled for 4:10 p.m. ET. Let's analyze BetMGM Sportsbook's lines around the Giants vs. Padresodds and make our expert MLB picks and predictions for the best bets.
Season series: Giants lead 2-1
San Francisco went 4 for 7 with runners in scoring position in a 9-6 win over San Diego Saturday. Over their 2 wins in this series, the Giants gave gone 9 of 18 in such situations.
The Padres had 3 extra-base hits Saturday. A San Diego club that last year tallied a league-average .413 slugging percentage has banged out 14 extra-base hits over its last 4 games.
Giants at Padres projected starters
RHP Daulton Jefferies vs. RHP Michael King
Jefferies has not pitched in the Majors since 2022; he missed last season recovering from his 2nd Tommy John surgery.
- Owns a 5.75 ERA over 14 career games (10 starts)
- Pitched 14 innings in spring training, logging a 2.57 ERA with 16 K against 3 BB
- Has never faced the Padres
King (4-8, 2.75 ERA with the New York Yankees in 2023) is making his 1st home start with the Padres after being acquired in the Juan Soto trade. Last season, he had a 1.15 WHIP, 2.8 BB/9 and 10.9 K/9 in 104 2/3 innings.
- Last outing: Win, 3 1/3 IP, 3 ER, 4 H, 3 BB, 5 K in 15-11 win vs. Los Angeles Dodgers March 21 (in South Korea)
- Has faced the Giants once, tossing 1 2/3 innings against them last April 1 (2 R allowed on 4 H and 1 BB; struck out 3)
- This game marks his 20th career start; he owns a 3.44 career ERA across 116 games overall
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Giants at Padres odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:35 a.m. ET.
- Moneyline: Giants +115 (bet $100 to win $115) | Padres -135 (bet $135 to win $100)
- Run line (RL)/Against the spread (ATS): Giants +1.5 (-175) | Padres -1.5 (+145)
- Over/Under (O/U): 8.5 (O: -115 | U: -105)
Giants at Padres picks and predictions
Prediction
Padres 5, Giants 4
Moneyline
There are too many questions on the Giants side of the ledger, especially with Jefferies getting the nod for the 1st time since May 18, 2022.
King will likely see a hefty contingent of left-handed batters in the San Francisco order, but the former Yankee relief standout has an excellent history against batters of the opposite hand (.656 OPS allowed career, .542 OPSA in 2023).
The Padres went 9-3 at home last September; they are 13-7 across their last 20 home games against San Francisco.
FanDuel Sportsbook has the best value price here: BET THE PADRES (-132).
Run line/Against the spread
PASS: Peg the ML as having the best leverage in this matchup.
Over/Under
The Over has cashed in all 3 games of this series.
Both offenses are clicking so far this season, and there are mound questions on both sides in this series finale. Last September, the Padres got on a roll at home. Over those last 12 games referenced above, they cranked out an .854 OPS while scoring 5.58 runs per game.
San Francisco banged out an .817 OPS in spring training, and batters on both sides get the likely benefit of a significant outward breeze, which is in the forecast. The game could also be in jeopardy due to expected heavy rain.
FanDuel Sportsbook has better leverage: BACK THE OVER 8.5 (-110).
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