The pair originally met in the '90s after their friends tried to set them up on a blind date.
"I don't even know if you remember this, but when I signed my deal sheet you gave me a call," Hostin told Shepherd.
"This is the magic of live television, everybody!"
The two have reportedly turned over a new leaf going into the new season.
Da Brat revealed on the talk show that she is five months pregnant.
Get ready for more of Leighton's lovable sass and sarcasm in the sophomore season of this hit HBO Max series!
McCain pulled an "I don't know her" on Shepherd, but still spent plenty of time ripping her apart.
You won't have to worry about any political debates here.
Shepherd has guest-hosted The Wendy Williams Show since Williams took medical leave last September.