Histone proteins are found in the nucleus of biological cells. They control which genes are active in cells and can be chemically modified in a variety of ways. Researchers have now provided an overview of how these modifications influence the development of stem cells into neurons and other brain cells. This could pave the way for new therapies against brain development disorders.
Researchers have investigated how drugs interact with the tiny channels through which neighbouring biological cells communicate with each other. The scientists have thus provided a possible explanation for the known neuropsychiatric side effects of an antimalarial drug. In addition, the new findings could enable the development of drugs against numerous other diseases.
