METRINO Project

#CRS2024 Reflecting on an impressive plenary lecture by Dr. Laura Sepp-Lorenzino, Ph.D. from Intellia Therapeutics, Inc., titled "Realizing the Promise of In Vivo CRISPR Therapeutics." Well in fact, it's more than a promise. Thanks to #Nanomedicine, we are now at the beginning of a true medical revolution. Dr. Sepp-Lorenzino delved into Intellia's pioneering work with CRISPR/Cas9 technologies delivered by systemic lipid nanoparticles (LNPs). Notably, onoing clinical trials have shown impressive improvements in patients with hereditary transthyretin amyloidosis (ATTR) and for hereditary angioedema (HAE), aiming to provide continuous reduction of symptoms with a single dose. HAE is a rare, autosomal dominant disorder characterized by recurrent episodes of severe swelling, which can be potentially fatal if not identified early and drastically impact the quality of life of patients. Current treatments are effective but expensive, and there is no cure yet. During the very active Q&A, Dr. Sepp-Lorenzino emphasized the key role of nanomedicine but also highlighted the variability in LNP quality (that we see in virtually all research papers nowadays): "I'm happy with my LNP... But...not all LNP are the same." she said. Couldn't agree more. At the European Technology Platform for Nanomedicine (ETPN Association), we are addressing these challenges, notably through two great European collaborative projects: METRINO Project: Producing SOPs and reference materials to help academia and industry better qualify and standardize nanomedicine, notably including LNPs indeed. NANOSPRESSO-NL: Revolutionizing the paradigm of Nanomedicine for rare diseases through bedside production of small batches of high-quality RNA-LNP, to bypass the many constraints of scale-up. We develop this concept for rare and orphan diseases like Methylmalonic acidemia (MMA), a metabolic genetic condition leading to the accumulation of substances in cells that cause damage to the brain, liver, kidneys, and other organs. We even integrate regulatory science research in the process to understand how this new concept could fit current and future regulations. I highly recommend all friends and colleagues of the Nanomedicine community to follow these two projects of interest, at least on LinkedIn. Get involved! :) This lecture truly underscored the transformative potential of CRISPR technology in modern medicine. What a fantastic period: finally, we can see treatments coming for those millions of patients who struggle with rare and orphan diseases. #CRS2024 #CRISPR #GeneTherapy #Nanomedicine #Innovation #Healthcare cc Raymond Schiffelers Olivia Lewis Marieke De Bruin Andreas Åslund Sven Even F. Borgos Solstice Pharmaceuticals B.V. UMC Utrecht Robin Schürmann Enrica Alasonati Leonardo Mortati Marco Monopoli Lorena Diéguez meriem lamghari Neill Liptrott Marco Monopoli Giovanni Tosi Steven Conlan Kathleen Spring et al.

🚀 READ & SHARE OUR LATEST ARTICLE! "Cutting-Edge Cryo-Characterisation for Lipid Nanoparticles" Discover how advanced surface chemical analysis techniques are revolutionizing the development and characterization ofnanomedicines. The METRINO Project is pioneering innovative approaches to ensure precise and detailed surface chemical analysis, providing deeper insights into the attributes enhancing the efficacy and stability of nanotherapeutics. These advancements hold immense potential for applications ranging from cancer treatment to advanced drug delivery systems. 🔬 Read the full article here: https://lnkd.in/euzdQKpy 🌟 Key Highlights: Explore the latest cryo-characterization techniques, including X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS). Learn how these methods provide unique insights into the lipid composition of individual nanoparticles and surface coatings. Understand the significance of measuring lipid composition on a particle-by-particle basis for optimizing nanotherapeutic designs. 🤝 Our Partners: We are proud to collaborate with esteemed organizations that make this groundbreaking research possible: National Physical Laboratory (NPL) European Technology Platform for Nanomedicine (ETPN Association)) Physikalisch-Technische Bundesanstalt, PTB) Curadigm LNE RISE Research Institutes of Sweden any many more! Join us in advancing nanomedicine! Share your thoughts and feedback in the comments below. For more information or to get involved, visit our website. #Nanomedicine #LipidNanoparticles #CryoCharacterisation #Nanotechnology #METRINO #HealthcareInnovation #ScientificResearch #LNP

🚀 Nanomedicine Experts: We Need You (for 5 minutes)! 🚀 In the rapidly evolving field of Clinical #Nanomedicine, your expertise is not just valuable—it's essential. The METRINO Project is spearheading an initiative that directly taps into your knowledge and experience. By participating in our quick survey, you have the unique opportunity to influence critical advancements in the use of liposomes, metal oxides, and lipid-based nanoparticles for RNA delivery and beyond. *Why Your Insight Matters: Your firsthand experience with #ADME, #biodistribution, and #pharmacokinetics of nanomedicine plays a pivotal role in guiding the METRINO project. Your insights will shape our focus on the most relevant nanoparticles, cell lines, tissues, and dosages, driving innovation and revolutionizing patient care in the European Metrology community. *Survey Highlights: 1) Your Nanoparticle Experience: Share your journey with various nanoparticles and your vision for future explorations. 2) Applications & Targets: Dive into the application contexts for nanoparticles, from diagnostic imaging to cancer therapy and gene therapy. 3) ADME & Beyond: Your perspectives on ADME studies, methodological gaps, and the desired stability for sample storage are invaluable. Take Action Now! Be a part of this transformative initiative. Your contributions will not only influence the METRINO project's direction but also contribute to the broader field of nanomedicine. 🔗 Join the Survey Here: https://lnkd.in/eXjjt2Hc cc European Technology Platform for Nanomedicine (ETPN Association) Physikalisch-Technische Bundesanstalt, PTB National Physical Laboratory (NPL) TÜBİTAK INRiM - Istituto Nazionale di Ricerca Metrologica SINTEF Empa LGC RISE Research Institutes of Sweden Università di Pavia

🔬 Upcoming Webinar Alert: "Standardisation and Validation Made Simple" 🔬 Join us for an enlightening session on April 9th, where we'll explore the foundational aspects of metrology and its critical role in the development of pharmaceuticals, cosmetics, and consumer products. This webinar, brought to you by METRINO Project in collaboration with the MACRAMÉ Project project and Association NanoMesureFrance, is a must-attend for anyone invested in the future of analytical sciences. 📅 When: April 9, 2024, 14:00 - 16:00 CET 🌐 Where: Online Why attend? Receive expert guidance from Dr. Georges Favre and Dr. Caterina Minelli. Understand the nuances of metrology and how it applies to your work. Connect with peers and leaders in #nanotechnology and #nanomedicine. Whether you're a researcher, student, or professional, this webinar will equip you with essential knowledge and skills in standardization practices. Let's drive innovation together. 👉 Register now and ensure your place in this pivotal discussion : https://lnkd.in/e9V8HRcg #METRINO #MACRAMEProject #Metrology #Standardization #Webinar Robin Schürmann Leonardo Mortati Enrica Alasonati Fanny Caputo

#BREAKING 🚨 METRINO Website Goes Live: A New Chapter in Nanomedicine Metrology! 🚀 We're thrilled to unveil today www.metrino.eu, a landmark digital platform where innovation meets precision in nanomedicine. Here's a glimpse of what you'll discover: 🔭Mission & Vision: Uncover the core objectives driving METRINO to redefine #metrology standards, fostering advancements in #nanomedicine that promise to revolutionize patient care. 📢News & Events : Discover the hot topics of the field and the upcoming opportunities yto join our journey. 🏆Results: our latest achievements on Reference Material Candidates (WP1), Advanced Characterisation (WP2), Sample Preparation and Particle Fractionaction in Biological Matrices (WP3), Particle Detection in Model Tissue Phantoms and Biological Tissues (WP4), Creating Impact (WP5), and Management (WP6) 📚Rich Resources: From meticulously crafted SOPs to groundbreaking reference materials, useful definitions, introduction to regulatory aspects, nanomedicine, ane more our repository is designed to empower researchers, clinicians, and industry stakeholders. 👥 Community & Collaboration: Join a vibrant network of experts committed to propelling nanomedicine from the lab bench to bedside, through shared knowledge and collaborative initiatives. We've also carefully included summary for non-expert audience on all pages, to make METRINIO as inclusive as possible of all nanomedicine enthusiasts. This website is the results of months of stimulating work and dedicated collaboration between our Partners. Special acknowledgments to our passionate team members and partners, including Fanny Caputo, Alexandre Ceccaldi, Robin Schürmann, Leonardo Mortati, Ute Resch-Genger, Enrica Alasonati, Caterina Minelli, from LNE, European Technology Platform for Nanomedicine (ETPN Association); Physikalisch-Technische Bundesanstalt, PTB, INRiM - Istituto Nazionale di Ricerca Metrologica, National Physical Laboratory (NPL) et and all whose contributions have been instrumental. 💡 METRINO in a nutshell The METRINO project, a cutting-edge European project financed by the EURAMET - The European Association of National Metrology Institutes, spearheads the advancement of nanomedicine metrology. The dynamic consortium unites 9 metrology institutes, 3 universities, 3 large RTOs, 2 pharmaceutical company and 1 SME producing innovative nanotherapeutics, 1 hospital and the ETPN association in the collaborative effort to refine measurement methods and create reliable reference materials associated to nano-enabled clinical formulations. Our mission is to support the quality control of #nanotherapeutics, including synthetic lipid-based particles such as liposomes and LNPs-RNA, and metal oxide nanoparticles, facilitating the seamless integration of nanomedicine into healthcare. Dive into metrino.eu to explore more and join us in shaping the future of healthcare. Please share te news ! #METRINO #liposomes #RNA #LNP #metaloxyde #Metrology

🔵 The Pillars of METRINO: A Snapshot 🔵 As we continue to navigate the intricacies of #nanomedicine and its standardization, it's essential to reiterate the core pillars that uphold our project's integrity and drive: 1) SOPs (Standard Operating Procedures): Our commitment to developing and harmonizing SOPs is not just about setting benchmarks. It's about fostering a unified approach to #nanomedicine #characterization, making these protocols widely accessible and establishing a gold standard for the community. 2) Reference Materials: We're not just shaping a roadmap; we're pioneering the journey for certified reference materials. Our collaborative efforts with industry leaders are aimed at ensuring that #LNPs, #liposomes, and metal oxide #nanoparticles not only meet the rigorous standards but also reflect the real-world formulations circulating in the market. 3) Community Building: Beyond the science and the systems, we are cultivating a collaborative ecosystem. By connecting metrology institutes, researchers, characterization experts, industry stakeholders, and regulators, we're building more than a network; we're nurturing a European community geared towards innovation and excellence. Each pillar is a testament to our dedication and our collective pursuit of excellence. As we share these foundations, we invite you to join us in this exciting journey of discovery and advancement. #METRINO #Nanomedicine #Metrology #Innovation #Standardization #Nanotechnology #Collaboration

🚀 Day 1 of METRINO Project's 2nd Project Meeting! Over 40 experts have joined online to review initial findings and tackle collective challenges. Here's a glimpse of our agenda: 🔬 Technical Progress Reports covering the preparation of diverse nanomaterials and their characterisation. ☕ Virtual Coffee Break to meet our new collaborators 🧬 Scientific challenges, focusing on #lipid-based nanoparticles and #metal oxide NPs, including characterisation techniques and method development. 📅 Future planning with open discussions for each Work Package (WP) to strategize upcoming activities. We're looking forward to a productive session with our Scientific Advisory Board members and all consortium partners. Stay tuned for updates! #Metrino #Nanomedicine #Standardization #Characterization #Nanomaterials #Nanoparticles European Technology Platform for Nanomedicine (ETPN Association) LNE INRiM - Istituto Nazionale di Ricerca Metrologica Physikalisch-Technische Bundesanstalt, PTB, TÜBİTAK, Nanobiotix Curadigm, National Physical Laboratory (NPL), Empa, SINTEF, Università di Pavia, Universiteit Gent, et al.

🚀 Launching METRINO: "Metrology for innovative nanotherapeutics " Welcome to the official LinkedIn page of #METRINO, a pioneering initiative launched under the European Union’s, funded by EURAMET - The European Association of National Metrology Institutes . This project commenced in June 2023 with the mission to redefine and streamline metrology standards in nanomedicine. 🌐 European Collaboration for Innovation: METRINO represents a significant European collaboration, uniting a consortium of leading academic institutions, industry experts, and research entities. Coordinated by Fanny Caputo from LNE, this project is a testament to Europe's commitment to advancing healthcare through innovative technology. 🤝 The consortium brings together 9 leading European NMIs in the field, complemented by 3 universities, 3 large RTOs, 2 pharmaceutical company and 1 SME producing innovative nanotherapeutics, 1 hospital and the European Technology Platform for Nanomedicine (ETPN Association) - in charge of Communication & Impact - are included in the consortium, providing the complementary expertise. 🔬 Our Key Focus Areas: 1) SOPs & Standards 2) Reference Materials 3) Bridging the metrology community on nanomedicine Each of these focal areas is designed to drive forward the integration of nanotechnology in medical applications, setting new benchmarks for accuracy and efficacy. 🔗 Stay Connected: While our comprehensive website is in development, please visit the LNE website for preliminary information: https://lnkd.in/ewGaeMTi. This LinkedIn page will serve as a dynamic hub for updates, insights, and discussions around METRINO’s journey. ✨ Join Us in Shaping the Future: By following our LinkedIn page, you become a part of a community dedicated to groundbreaking advancements in nanomedicine metrology. We invite you to engage with us as we embark on this exciting and transformative journey. #METRINO #Nanomedicine #Metrology #EuropeanInnovation #HealthcareTechnology cc SINTEF TÜBİTAK RISE Research Institutes of Sweden Curadigm Nanobiotix Empa National Physical Laboratory (NPL) nanoPET Pharma GmbH Universiteit Gent Otto-von-Guericke University Magdeburg Physikalisch-Technische Bundesanstalt, PTB, SMD, et al.